Investigación

What are we doing?

In this section you will find all information about our research activity

The general objective has ever been the development of electrochemical (bio)sensors. Our current interests are focused in the development of biosensor using nucleic acids as a molecular recognition element, either using aptamers or the hybridization reaction, to solve problems in the biomedical field.
We are now focused on more specific and sensitive in-vitro diagnostic methods of cancer. Cancer is one of the main causes of mortality in the world and its early detection is one of the most challenging issues faced in this century. The advances in the knowledge of this group of diseases specifically the tumor microenvironment, the post-translational modifications of proteins and transcriptomics, opens new avenues for finding more specific biomarkers. The personalized diagnostic based on these new biomarkers must be accompanied to novel non-invasive methods of detection (liquid biopsy) that allow to diagnose at an early stage. Biosensors offer excellent opportunities to meet the extreme requirements of sensitivity in cancer diagnosis and prognosis, and also as a companion methods to guide therapeutic intervention. However, its develpment is limited by the availability of receptors of high selectivity and affinity to recognize the target.
 
To fill this gap our specific aims are:
• Selection of aptamers for tumor biomarkers with special focus on glycosylation pattern and extracelullar matrix components and the development of biosensors and methods of analysis for biomarker detection.
• The selection of long noncoding RNA overexpressed in cancer and the design of hybridization devices to selective quantify them by integrating isothermal nucleic-acid amplification methods with electrochemical detection.

 

 
 
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